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primobolan results

It has no effect on the release of pituitary hormones gonadotropin, thyroid-stimulating hormone, and somatotropin. It does not affect the concentrations of cortisol, aldosterone, androgen or estrogen, sperm motility, sperm quantity and composition, as well as does not have antiandrogenic actions. It may primobolan results weaken the release of vasopressin. Increases gastric mucosal protective mechanisms and helps heal her injuries associated with exposure to hydrochloric acid (including cessation of gastrointestinal bleeding and scarring of stress ulcers), by increasing the formation of gastric mucus, its content of glycoproteins, stimulating the secretion of bicarbonate gastric mucosa endogenous synthesis of prostaglandins in it and recovery rate.At a dose of 150 mg suppresses gastric acid secretion for 8-12 hours. Inhibits microsomal enzymes.

 

Treatment and prevention of gastric ulcers and 12 duodenal ulcer, NSAID-gastropathy, heartburn (associated with hyperacidity), hypersecretion of gastric juice, symptomatic ulcers, stress ulcers of the gastrointestinal tract (GIT), erosive esophagitis, reflux esophagitis, Zollinger-Ellison syndrome, systemic mastocytosis, multiple endocrine adenomatosis; dyspepsia, characterized by epigastric or retrosternal pain associated with eating or disturbs sleep but not caused by the above conditions; treatment of bleeding from the upper gastrointestinal tract, prevention of recurrence of gastric bleeding in the postoperative period; prevention of aspiration of gastric juice in patients who carried out the operation under general anesthesia (Mendelson’s syndrome); prevention of aspiration pneumonitis; as adjuvant therapy in the treatment of rheumatoid arthritis.

Contraindications
: Hypersensitivity to ranitidine or other components of the drug.
Pregnancy, lactation.
Children under 12 years old.

Precautions
Renal and / or hepatic failure, cirrhosis with encephalopathy (disorder), acute porphyria (also in history), immunosuppression.

Dosing and Administration
Inside adults and children over 12 years, regardless of the meal, not liquid, squeezed small amounts of liquid.

Peptic ulcer and 12 duodenal ulcer. For the treatment of exacerbations appoint 150 mg 2 times a day (morning and evening) or 300 mg at night. If needed – 300 mg 2 times a day. Course duration lecheniya- 4-8 weeks. For the prevention of relapse appoint 150 mg at night.

NSAID gastropathy. At 150 mg two times daily or 300 mg at night for 8-12 weeks. Prevention of the formation of ulcers when taking NSAIDs – 150 mg 2 times a day.

Postoperative ulcer. According 150 mg 2 times a day for 4-8 weeks.

Gastroesophageal reflux disease. 150 mg 2 times a day, or 300 mg at night if required dose can be increased up to 150 mg four times a day. The course of treatment 8-12 weeks. When I-II art. the severity of reflux esophagitis, increase the dose to 600 mg / day in 4 divided doses for 12 weeks. Long-term prophylactic therapy -150 mg 2 times a day

Zollinger-Ellison syndrome. The initial dose of 150 mg three times a day dose may be increased to 6 g / day, if necessary.

Prophylaxis of recurrent bleeding. 150 mg 2 times a day.

Prophylaxis of Mendelson’s syndrome. Assign a dose of 150 mg 2 hours before anesthesia, and preferably also 150 mg the previous evening.

Episodes in chronic dyspepsia – 150 mg 2 times a day for 6 weeks.
Babies for treating peptic ulcers – inside, 2-4 mg / kg two times a day; with reflux esophagitis 2-8 mg / kg 3 times a day; the maximum daily dose – 300 mg.

Patients with impaired renal function require correction mode. When creatinine clearance less than 50 ml / min, the recommended primobolan results dose is 150 mg per day, the presence of concomitant liver function abnormalities may require further dose reduction. Patients who are on hemodialysis, another dose administered immediately after hemodialysis.

Side effect From the digestive system: nausea, dry mouth, constipation, vomiting, diarrhea, abdominal pain; rarely – hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.

From the side of hematopoiesis: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, bone marrow hypo- and aplasia of immune hemolytic anemia.

Cardio-vascular system: decrease in blood primobolan results pressure, bradycardia, arrhythmias, AV-block.

From the nervous system: fatigue drowsiness; rare – confusion, tinnitus, irritability, hallucinations (mainly in the elderly and critically ill patients), involuntary movements.

From the senses: blurred vision, paresis of accommodation.

From the musculoskeletal system: arthralgia, myalgia.

From endocrine system: hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.

Allergic reactions: urticaria, skin rash, angioedema, anaphylactic shock, bronchospasm, erythema multiforme.

Other: alopecia, hypercreatininemia.

Overdose
symptoms: convulsions, bradycardia, ventricular arrhythmias.
Treatment: symptomatic. It is shown that the induction of vomiting and / or gastric lavage. With the development of convulsions – diazepam intravenously, with bradycardia – atropine, ventricular arrhythmia – lidocaine. Hemodialysis is effective.

The interaction with other drugs
increases AUC (area under the concentration-time curve) and the concentration of metoprolol in the blood serum (respectively 80 and 50%), the T1 / 2 Metoprolol increased from 4.4 to 6.5 hours.

It reduces absorption of itraconazole and ketoconazole.

It inhibits hepatic metabolism phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, nifedipine, warfarin, diazepam, lidocaine, phenytoin, theophylline, aminophylline, indirect anticoagulants, glipizide, buformina, metronidazole, calcium channel blockers slow.

Increasing the concentration of procainamide.

Antacids, sucralfate slow down the absorption of ranitidine (while the application of the break between taking antacids and ranitidine should be at least 1-2 hours).

Drugs that suppress the bone marrow to increase the risk of neutropenia.

Smoking decreases the effectiveness of ranitidine.

Cautions
symptoms of peptic ulcer disease 12 duodenal ulcer may disappear within 1-2 weeks, but therapy should be continued for as long as the scarring is not confirmed by endoscopy or X-ray examination.

May mask symptoms associated with carcinoma of the stomach, so before starting treatment to rule out malignancy Ranitidine undesirable sharply cancel ( “ricochet” syndrome).

With long-term treatment of patients with weakened under stress may be bacterial lesions of the stomach and then spread the infection.

Blockers H 2 histamine receptors to be taken 2 hours after administration of ketoconazole or itraconazole avoid significant reduction of absorption. Can cause false positive reaction in the test of protein in urine.

Increases creatinine, GGT (gamma-glutamyl) and serum transaminases.

Protivodeystvodeystvuet influence on histamine and pentagastrin gastric acid-forming function, therefore, the foregoing test, it is not recommended for 24 hours.

Suppress skin reaction to histamine, thus leading to false-negative results (prior to diagnostic skin testing is recommended to stop to detect immediate allergic skin reaction such as drug use).

Efficacy in inhibiting nocturnal acid secretion in the stomach may decrease as a result of smoking.

During treatment should avoid eating foods, drinks and other drugs that can cause irritation of the gastric mucosa.

During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

Composition
Tablets, film-coated, 150 mg and 300 mg.
10 tablets in a strip of aluminum foil laminated with polyethylene film nyzkoy density. 2 or 10 strips packed in a cardboard box with instructions for use.

Storage conditions
List B.
In dry, dark place at a temperature no higher than 25 ° C.
Keep out of reach of children!

Shelf life
3 years.
Do not use after the expiration date printed on the package.

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