Cefuroxime relates to cephalosporin antibiotics II generation. Cefuroxime is active against a broad spectrum of pathogens, including strains that produce beta-lactamase. Cefuroxime has primobolan for sale good resistance to bacterial beta-lactamases and, accordingly, is active against a broad spectrum of ampicillin and amoksitsillinrezistentnyh strains. The bactericidal action of cefuroxime associated with suppression of bacterial cell wall synthesis by binding to the major target proteins. Cefuroxime is usually active in vitro against the following primobolan for sale microorganisms Escherichia coli Klebsiella spp. Proteus mirabilis Providencia spp. Providencia rettgeri Haemophilus influenzae (including ampitsillinrezistentnye strains )(including ampitsillinrezistentnye strains) Moraxella catarrhalis Neisseria gonorrhoeae (including penicillinase and penicillinase-producing strains) Aerobes gram-positive: and Staphylococcus epidermidis (including penicillinase-producing strains but excluding methicillin-resistant (andstrains) other beta-hemolytic streptococci) of Streptococcus pneumoniae of Streptococcus group B ( of Streptococcus agalactiae ) of Streptococcus mitis (group viridans ) of Bordetella pertussis gram-positive and gram-negative cocci (including Peptococcus and species Peptostreptococcus ) gram-positive rods (including most species of Clostridium ) and gram-negative bacilli (including Bacteroides and species Fusobacterium) Propionibacterium spp. Gram-negative spirochete (includingBorrelia spp.) Clostridium difficile Pseudomonas spp. Campylobacter spp. Acinetobacter calcoaceticus Listeria monocytogenes methicillin-resistant strains of Staphylococcus aureus methicillin-resistant strains of Staphylococcus epidermidis Legionella spp. Enterococcus faecalis Morganella morganii the Proteus vulgaris . of Enterobacter spp Citrobacter spp. of Serratia spp. of Bacteroides fragilis
The maximum concentration of cefuroxime in the plasma after intramuscular administration is noted in a period of 30 to 45 minutes. Distribution Relationship with plasma proteins is 33-50%. Cefuroxime penetrates the blood-brain barrier, the placenta and breast milk. Therapeutic concentrations of cefuroxime are created in bone, skin , soft tissue, synovial, pleural, intraocular fluid, bile, sputum and myocardium. Cefuroxime concentration exceeding the minimum inhibitory concentration for most microorganisms can be achieved in bone tissue, synovial and ocular fluids. Metabolism Cefuroxime is not metabolized. Elimination half-life of cefuroxime serum after parenteral administration is about 70 minutes. In newborn infants, the half-life of cefuroxime can be 3-5 times longer than in adults. Cefuroxime is excreted by the kidneys by glomerular filtration and tubular secretion. Concomitant probenecid prolongs the excretion of cefuroxime, which leads to an increase in the maximum serum concentrations of cefuroxime. Within 24 hours after parenteral administration Cefuroxime is almost completely (85-90%) is output from the kidneys in unchanged form, with most of the product -. for the first 6 hours Serum levels of cefuroxime are reduced by dialysis.
Indications for use of
treatment of diseases caused by bacteria sensitive to cefuroxime, and when the exciter is not yet determined:
- infections of the upper and lower respiratory tract infections: bacterial pneumonia, acute and chronic bronchitis, infected bronchiectasis, lung abscess, postoperative, infectious diseases of the chest;
- infections of upper respiratory tract: otitis media, sinusitis, tonsillitis, pharyngitis;
- urinary, tract infections: acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria;
- Gonorrhoea, particularly when penicillin therapy is not indicated;
- infections, skin and soft tissue: cellulitis, erysipelas and wound infections;
- bone and joint infections: osteomyelitis and septic arthritis;
- pelvic infection;
- other infections including septicemia, meningitis, peritonitis;
- prevention of infectious complications during operations on the abdominal, pelvic, orthopedic surgery, heart primobolan for sale surgery, lung, esophagus and blood vessels.
Contraindications for use
Hypersensitivity to cephalosporin antibiotics, penicillins and carbapenems history.
should be used with caution in patients with renal failure, diseases of the gastrointestinal tract (including the history and ulcerative colitis), if necessary combined – purpose with loop diuretics and aminoglycosides, in the early stages of pregnancy and during lactation, as well as in newborns (especially premature).
Pregnancy and lactation
There are no data on the development of embryotoxic or teratogenic effects of cefuroxime, but we must be careful in appointing him during pregnancy. The drug belongs to the category V. Cefuroxime is excreted in breast milk, so you should be careful in appointing him nursing mothers.
Dosage and administration
Cefuroxime is also available in the form of cefuroxime axetil (Zinnat ® ) in the form of tablets and suspension for oral administration.
Permissible to replace parenteral therapy with oral therapy with appropriate indications.
The recommended dose is 750 mg 3 times a day intramuscularly or intravenously.
In more severe cases, medication is primobolan for sale administered intravenously at a dose of 1.5 g 3 times a day. If necessary, drug Zinatsef ® can be administered every 6 hours, and the daily dose can be from 3 to 6 g
When some infections effectively assignment, drug Zinatsef ® at a dose of 750 mg; 1,5g or 2 times per day (intramuscularly or intravenously) followed by administration of the drug Zinnat ® (cefuroxime in the dosage form for oral administration).
recommended dose is 30-100 mg / kg / day, divided into 3-4 administration.
For most infections optimum dose is 60 mg / kg / day.
recommended dose is 30-100 mg / kg / day, divided into 2-3 administration.
recommended dose is 1.5 g once (two doses of 750mg intramuscularly to different places for injection, for example, both the buttocks).
drug Zinatsef ® is recommended as the basic therapy of bacterial meningitis.
The recommended dose is 3 g intravenously every 8 hours.
recommended dose is 150-250 mg / kg / day intravenously divided into 3-4 administration.
The recommended dose is 100 mg / kg / day intravenously.
Prevention of postoperative complications
With operations in the abdominal, pelvic and orthopedic interventions, drug Zinatsef ® at a dose of 1.5 g administered intravenously during induction of anesthesia. After 8 and 16 hours after surgery may further bgg administered intramuscularly to 750 mg of the drug Zinatsef ® .
In heart surgery, lung, esophagus and blood vessels during the induction of anesthesia drug Zinatsef ® intravenously in a dose of 1.5 g, and then for 24-48 h at 750 mg three times a day intramuscularly.
In total joint prosthesis 1.5 g cefuroxime dry powder can be mixed with the contents of each packet from methyl methacrylate polymer cement before the addition of the liquid polymer.
duration parenteral and oral antibiotic therapy is determined depending on the severity of the infection and the clinical picture.