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primobolan acetate

It prevents the development and facilitates the allergic reactions, has antipruritic and protivoekssudativnoe action. It affects the “early” stage gistaminozavisimuyu allergic reactions primobolan acetate limits the release of inflammatory mediators on “late” stage of an allergic reaction, reduces migration of eosinophils, neutrophils and basophils, mast cell stabilizing membrane. Decreases capillary permeability, prevents the development of edema, reduces smooth muscle spasm. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as cooling (when cold urticaria). Reduces gistaminoindutsirovannuyu bronchoconstriction in asthma lung flow. Virtually no anticholinergic and antiserotoninovogo action. At therapeutic doses, virtually no sedative effect.Quickly absorbed by ingestion. The maximum serum concentration achieved after 1 hour after oral administration. Food does not affect the absorption of completeness, but lengthens the process of absorption for 1 hour.


For adults and children from 6 months of age and older: the treatment of the symptoms of year-round and seasonal allergic rhinitis and allergic conjunctivitis, such as itching, sneezing, rhinorrhea, lacrimation, conjunctival hyperemia; hay fever (hay fever); urticaria, including chronic idiopathic urticaria, angioedema; and other allergic dermatoses, including atopic dermatitis, accompanied by itching and rashes.



Chronic renal failure (moderate and severe degrees of severity), advanced age (perhaps decreased glomerular filtration).

Dosing and Administration
Children from 6 months to 12 months: 2.5 mg (5 drops), 1 per day.
Children from 1 year to 2 years: 2.5 mg (5 drops) to 2 times a day.
Children from 2 to 6 years: 2.5 mg (5 drops), 2 times per day or 5 mg (10 drops) 1 time per day.

Adults and children over 6 years: daily dose – 10 mg (1 tablet or 20 drops). Adults – 10 mg 1 time a day; children 2 to 5 mg twice a day or 10 mg once daily. Sometimes 5 mg starting dose may be sufficient to achieve a therapeutic effect.

Patients with renal insufficiency dose reduced primobolan acetate according to creatinine clearance: with creatinine clearance 30-49 ml / min – 5 mg 1 time per day; at 10-29 ml / min – 5 mg every other day.

Side effect

Drowsiness, headache, dry mouth; rarely – headache, dizziness, migraine, diarrhea, allergic reactions: angioneurotic edema, pruritus, rash, urticaria.


When taking the drug once daily 50 mg dose over the following symptoms may occur: sleepiness, restlessness and irritability, urinary retention, dry mouth, constipation, mydriasis, tachycardia. If symptoms of overdose the drug should be discontinued, it is necessary to wash out the stomach, take activated charcoal, seek medical advice immediately.

Interaction with other drugs

There were no pharmacokinetic interactions and clinical benefit with a joint appointment with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, diazepam, glipizide. When coadministered with theophylline at a dose of 400 mg 1 time per day, there was a reduction in creatinine clearance by 16%. At a joint appointment with the macrolides and ketoconazole is not marked ECG changes.

When used in therapeutic doses, no evidence of interaction with the alcohol (for BAC 0.5 g / L). However, it is primobolan acetate best to abstain from alcohol during treatment with cetirizine.

special instructions

When an objective quantification of the ability to drive a car and operate machinery does not reliably identify any adverse events in the appointment of the recommended dose of 10 mg, however, recommended caution.

release Form

Film-coated tablets in blister packs for 7 or 10 tablets packed in one blister with instructions for use in a cardboard box.

Drops for reception inside : In 10 ml or 20 ml of solution in dark glass bottles (Type 3), sealed with a polyethylene cap, equipped with protection system of children. The bottle cap is provided with a dropper of white low-density polyethylene. Bottle with instruction on use is placed in a cardboard box.

Storage conditions

Film-coated tablets: in a dry place at temperatures below 25 ° C.

Drops for reception inside: at a temperature no higher than 25 ° C.

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