Absorption: After oral cetirizine rapidly and well absorbed from the gastrointestinal tract. Maximum concentration level is determined after about 30 -60 minutes.
Food intake has no significant effect buy primobolan on the amount of absorption, but in this case, the rate of absorption is significantly reduced.The drug does not penetrate through gemagoentsefalichesky barrier.Metabolism. Cetirizine poorly metabolized in the liver with the formation of the inactive metabolite
At 10 days of administration at a dose of 10 mg of drug accumulation is observed.After a single administration of a single dose of the value of half-life is about 10 hours. In children aged 2 to 12 years the value of half-life is reduced to 5 to 6 hours.
If the kidney function (creatinine clearance below 11-31 ml / min) and in patients on hemodialysis (creatinine clearance less than 7 ml / min), the value of half-life increased by 3 times, the clearance is reduced by 70%.
Against the background of chronic diseases and elderly patients have an increase in the value of the half-life by 50% and a decrease in clearance of 40%.
Hemodialysis is ineffective.
Indications for use:
- Seasonal and perennial allergic rhinitis and conjunctivitis;
- Itchy allergic dermatitis;
- Hay fever (hay fever);
- Urticaria (including chronic idiopathic);
Contraindications for use:
- Hypersensitivity to the drug.
- End-stage renal failure (creatinine clearance <10 mL / min).
- Hereditary galactose intolerance, the lack of lactase, or syndrome of glucose-galactose malabsorption.
- Children under 6 years of age.
- Pregnancy, lactation.
Chronic renal failure secondary to buy primobolan severe (requires correction mode), advanced age (perhaps decreased glomerular filtration).
Dosing and Administration
The drug Zodak used by a physician to prevent complications.
Inside, regardless of meals.
Adults and children over the age of 12 years,
drug Zodak usually prescribed to 1 coated tablet (= 10 mg of cetirizine), once a day.
Children aged 6 to 12 years of
drug Zodak usually prescribed to 1 coated tablet (= 10 mg of cetirizine), once a day or 1/2 coated tablet (= 5 mg of cetirizine), twice a day, in the morning and in the evening.
Patients with renal insufficiency dose reduced according to creatinine clearance (CC): with CC 30-49 ml / min – 5 mg once daily; at 10-29 ml / min – 5 mg every other day.
When administering the drug to patients with renal failure and patients older dose should be adjusted depending on the value of KK.
possible confusion, dizziness, drowsiness, confusion, stupor, weakness, anxiety, irritability, sedation, fatigue, headache, mydriasis, pruritus, tachycardia, tremor, urinary retention, dry mouth, diarrhea, constipation (often with receiving daily 50 mg of cetirizine), malaise.
symptomatic therapy. A specific antidote is not revealed.
Hemodialysis is ineffective. Perform gastric lavage. activated charcoal.
Interaction with other drugs
Not established clinically significant interactions of cetirizine with other drugs.
Co-administration with theophylline (400 mg / d) reduces the total clearance of cetirizine (kinetics of theophylline is not changed).
In the period of treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Caution should be exercised in patients with impaired liver and / or kidney disease, and the elderly.
Not recommended simultaneous buy primobolan use of drugs which depress the central nervous system, alcohol.
Tablets, film-coated, 10 mg.
At 7 or 10 tablets in PVC / PVDC / A1 blister. Each blister 7 tablets; 1, 3, 6, 9, or 10 blister packs of 10 tablets, together with instructions for use in a cardboard box.