The time to reach maximum blood concentration with the / m administered in a dose of 0.5 g and I r is 2 hours and 1 hour; maximum concentration. It penetrates the joints, the tissue of the cardiovascular system, into the abdominal cavity, the kidney and urinary tract, placenta, middle ear, respiratory tract, skin and soft tissue. In small amounts excreted in breast milk. The primobolan side effects concentration in the tissue of the gallbladder and bile is significantly higher than in plasma. When obstruction of the gallbladder bile concentration lower than in plasma. The volume of distribution.
Hypersensitivity to the drug group of cephalosporins and other beta-lactam antibiotics. Pregnancy and lactation. Babies up to 1 month.
Renal / hepatic failure, pseudomembranous colitis, bowel diseases, children under 1 year.
Dosage and administration
Dosage is determined individually taking into account the severity and localization of infection susceptibility, the patient’s age. The drug can be administered intramuscularly, intravenously (bolus or infusion).The average daily dose for adults is 1-4 g; frequency of administration – 3-4 times per day. The maximum daily dose – 6 The average duration of treatment is 7-10 days.
For the prevention of postoperative infection is administered intravenously 1 g for 0.5-1 hours primobolan side effects before the operation, 0.5-1 g during surgery and at 0.5-1 g every . 8 hours during the first day after surgery
in patients with impaired renal function requires a change in dosing regimen based on the values of creatinine clearance (CC): QA 55 mL / min or more, or when the creatinine concentration in the plasma of 1.5 mg% or less can be administered full dose; with CC 54-35 ml / min or serum creatinine concentration in the plasma of 3-1.6 mg% can enter the full dose, but should increase the interval between injections to 8 hours; QC at 34-11 ml / min or plasma creatinine concentration in mg 4.5-3,1% – 01.02 doses at intervals of 12 hours; QC at 10 ml / min or less or plasma creatinine concentration 4.6 mg% or more -. 1/2 the usual dose every 18-24 hours, all the recommended doses are applied after introduction of the initial dose, the respective severity of the infection. Children 1 month of age or older – 20-50 mg / kg / day; in severe infections the dose may be increased to 100 mg / kg / day. Multiplicity of – 3-4 times per day. Children with impaired renal function dosing regimen correction is carried out depending on the QC values: with CC 70-40 ml / min – 60% of the average daily dose and administered every 12 hours; QC at 40-20 ml / min – 25% of the average daily dose with an interval of 12 h; . with KK 5-20 ml / min – 10% of the average daily dose every 24 hours, all the recommended doses are applied after introduction of the initial dose, the respective severity of the infection. Preparation of solutions for intramuscular injection: 0.25 g of product was dissolved in 1 ml of water for injection 0.5 g – in 2 ml of water for injection, 1 g – 4 ml of water for injection or 0.9% sodium chloride solution, or 0.25 -. 0.5% procaine solutionfor intravenous drip preparation is dissolved in 50-100 ml chloride or 0.9% sodium chloride 5.10% dextrose solution, depending on the dose; infusion is carried out for 20-30 minutes (introduction rate of 60-80 drops per minute). For intravenous single bolus dose of 10 ml diluted in 0.9% sodium chloride and injected slowly over 3-5 min. During the breeding vials vigorously shaken until complete dissolution.
Side effects: Allergic reaction: pyrexia, rash, urticaria, pruritus, bronchospasm, eosinophilia, angioedema, arthralgia, anaphylactic shock, erythema multiforme, a malignant exudative erythema (Stevens-Johnson syndrome). From the nervous system: cramps Urinary system : in patients with kidney disease when treatment with high doses of cefazolin (6 g) may appear impaired renal function. In these cases, the dose reduced, and treatment is carried out under the control of the dynamics of urea nitrogen and creatinine in the blood. From the digestive system: nausea, vomiting, diarrhea, abdominal pain, pseudomembranous colitis, in rare cases – cholestatic jaundice, hepatitis. From the side of hematopoiesis: leukopenia, neutropenia, thrombocytopenia, thrombocytosis, haemolytic anemia. in the long-term treatment – goiter, superinfection, caused by antibiotic-resistant strains, candidiasis (including oral candidiasis). Laboratory findings: positive Coombs’ test, increased activity of “liver” transaminases, hypercreatininemia, increased prothrombin time. Local reactions: intramuscular injection of the drug, in rare cases -boleznennost the site of injection, by intravenous injection – phlebitis.
Overdose symptoms: pain, inflammatory reactions and phlebitis at the injection site; . dizziness, headache, paresthesia, seizures may develop (particularly in patients with kidney disease) Laboratory findings: an increased concentration of creatinine, BUN, liver enzymes and bilirubin; . thrombocytosis treatment: immediately stop the injection of the drug, to carefully monitor the vital functions of the body and the relevant laboratory parameters; therapy – symptomatic. In severe cases it is possible hemodialysis. Peritoneal dialysis is not efficient.
Interaction with other drugs
should not be used cefazolin with antibacterial drugs, have bacteriostatic mechanism of action (tetracyclines, sulfonamides, macrolides, lincosamides, chloramphenicol), because in vitro studies have shown that there is an antagonism between them.
With the simultaneous use of oral anticoagulants or high doses heparin blood clotting parameters need to be monitored. Aminoglycosides increase the risk of kidney damage. Pharmaceutical incompatible with aminoglycosides (mutual inactivation).
Drugs that block tubular secretion, including probenecid, slow excretion, increase the concentration in the blood primobolan side effects and increase the risk of toxic reactions
Patients who had a history of allergic reactions to penicillins, carbapenems, may be sensitive to cephalosporin antibiotics. During treatment with cefazolin may receive false-positive direct and indirect Coombs test, as well as false positive reaction on urine glucose. In appointing the drug may increase gastrointestinal disease, particularly colitis. If you have severe persistent diarrhea should take into account the likelihood of developing pseudomembranous colitis associated with the use of antibiotics. In this case, immediately stop treatment cefazolin and prescribed the appropriate treatment (use of drugs affecting peristalsis, are contraindicated).
The safety of preterm infants and children in the first months of life has not been established.
Powder for solution for intravenous and intramuscular administration of 250 mg, 500 mg and 1,000 mg.
The amount of drug equivalent to 250 mg, 500 mg or 1000 mg of cefazolin, the vial of clear glass, a sealed rubber septum, crimped aluminum cap and closed plastic primobolan side effects lid. 1 bottle with instruction on use is placed in a cardboard box; 5, 20 or 50 vials, together with instructions for use placed in a cardboard box (for hospitals).
In a dry, dark place at a temperature no higher than 25 ° C. Do not freeze. List B.
Keep out of reach of children.